THOR METHYLATION PROVIDES INSIGHT INTO THE TELOMERE MAINTENANCE LANDSCAPE OF MALIGNANT GLIOMAS

New insight into telomere maintenance

Szostak for their seminal discovery of telomere and telomerase. Telomere is a compact DNA-protein structure at the end of chromosome, comprised of TTAGGG repeats in humans and proteins associated with the telomeric sequence. When DNA replication starts, both strands of DNA are synthesized in opposite directions. The leading strand moves continuously, while the lagging strand is generated discon...

SURVIVAL IN PATIENTS WITH MALIGNANT GLIOMAS OF THE BRAIN

The present retrospective study was designed to analyze factors with prognostic values a) within, and b) significantly associated with, short-term (12months or less) and long-term (more than 24 months) survival times, i n 72 consecutive patients treated for malignant gliomas. Among 41 (57%) short-term surviving patients, the absence of both aphasia and motor deficit (as initial presenting ...

Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas

High-grade astrocytoma of WHO grade 4 termed glioblastoma multiforme (GBM) is a common human brain tumor with poor patient outcome. Astrocytoma demonstrates two known telomere maintenance mechanisms (TMMs) based on telomerase activity (TA) and on alternative lengthening of telomeres (ALT). ALT is associated with lower tumor grades and better outcome. In contrast to ALT, regulation of TA in tumo...

Mitophagy: New Insight into the Cardiovascular Aging  

Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1).

Methylation of cytosine in DNA plays a crucial role in development through inheritable gene silencing. The DNA methyltransferase Dnmt1 is responsible for the propagation of methylation patterns to the next generation via its preferential methylation of hemimethylated CpG sites in the genome; however, how Dnmt1 maintains methylation patterns is not fully understood. Here we report the crystal st...